Made in the EU Health registration 26.025358/GI EU-authorised health claims

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Science library

Magnesium and vitamin B6 studies

Magnesium takes part in hundreds of reactions in your body and vitamin B6 works in the same processes. These are the papers that explain their role, how much we need and how to choose the best form.

  • 13key studies
  • 2009–2025years of research
  • 4study types

13 key studies from 2009 to 2025, with a link to the original source.

2020-2026

  1. 2025

    ReviewIntake

    Magnesium: Health Effects, Deficiency Burden, and Future Public Health Directions

    Nutrients · 2025

    What was studied
    Reviewed the health effects of magnesium, the burden of deficiency and future public health directions.
    Key point
    The most up-to-date view on the importance of covering magnesium intake.
    Read the source
  2. 2024

    ReviewGeneral

    Magnesium Matters: A Comprehensive Review of Its Vital Role in Health and Diseases

    Cureus · 2024

    What was studied
    A comprehensive review of the role of magnesium in the body.
    Key point
    One of the most recent syntheses on magnesium and its functions.
    Read the source
  3. 2023

    Scientific opinionSafety

    Scientific opinion on the tolerable upper intake level for vitamin B6

    EFSA (NDA Panel) · EFSA Journal · 2023

    What was studied
    Reviewed the tolerable upper intake level for vitamin B6.
    Key point
    Set the maximum for adults at 12 mg per day from diet and supplements combined. Our serving provides 6 mg.
    Read the source
  4. 2021

    ReviewVitamin B6

    Vitamin B6 in Health and Disease

    Stach K. et al. · Nutrients · 2021

    What was studied
    Reviewed the role of vitamin B6 in the body.
    Key point
    Details its function as a coenzyme in more than a hundred reactions.
    Read the source
  5. 2021

    Systematic reviewForms

    Bioavailability of magnesium food supplements: A systematic review

    Pardo M.R. et al. · Nutrition · 2021

    What was studied
    Reviewed the studies on the bioavailability of the different forms of magnesium in supplements.
    Key point
    Analyses how chemical form and dose influence magnesium absorption.
    Read the source

2010-2019

  1. 2018

    Clinical trialMagnesium + B6

    Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial

    Pouteau E. et al. · PLoS One · 2018

    What was studied
    Compared magnesium with vitamin B6 against magnesium alone in healthy adults with stress and low blood magnesium.
    Key point
    One of the landmark trials on the combination of magnesium and vitamin B6.
    Read the source
  2. 2018

    ReviewGeneral

    Magnesium and Human Health: Perspectives and Research Directions

    Al Alawi A.M., Majoni S.W., Falhammar H. · International Journal of Endocrinology · 2018

    What was studied
    Reviewed magnesium physiology and current lines of research.
    Key point
    A map of the research perspectives on magnesium and health.
    Read the source
  3. 2017

    ReviewGeneral

    The Importance of Magnesium in Clinical Healthcare

    Schwalfenberg G.K., Genuis S.J. · Scientifica · 2017

    What was studied
    Reviewed the importance of magnesium in clinical practice.
    Key point
    Highlights the role of magnesium in multiple body systems.
    Read the source
  4. 2015

    Scientific opinionIntake

    Scientific Opinion on Dietary Reference Values for magnesium

    EFSA (NDA Panel) · EFSA Journal · 2015

    What was studied
    Set the magnesium reference values for the European population.
    Key point
    Adequate intake of 350 mg per day for adult men and 300 mg for adult women.
    Read the source
  5. 2015

    ReviewPhysiology

    Magnesium in man: implications for health and disease

    De Baaij J.H.F., Hoenderop J.G.J., Bindels R.J.M. · Physiological Reviews · 2015

    What was studied
    A major review of the role of magnesium in the human body.
    Key point
    Details its role as a cofactor for hundreds of enzymes and in forming the Mg-ATP complex.
    Read the source
  6. 2012

    ReviewIntake

    Suboptimal magnesium status in the United States: are the health consequences underestimated?

    Rosanoff A., Weaver C.M., Rude R.K. · Nutrition Reviews · 2012

    What was studied
    Analysed the magnesium status of the US population.
    Key point
    Pointed out that a large part of the population does not reach the recommended magnesium intake.
    Read the source
  7. 2010

    Scientific opinionRegulation

    Scientific Opinion on the substantiation of health claims related to magnesium

    EFSA (NDA Panel) · EFSA Journal · 2010

    What was studied
    Assessed new health claims for magnesium.
    Key point
    Completed the scientific basis of the authorised magnesium claims.
    Read the source

2002-2009

  1. 2009

    Scientific opinionRegulation

    Scientific Opinion on the substantiation of health claims related to magnesium

    EFSA (NDA Panel) · EFSA Journal · 2009

    What was studied
    First assessment of the health claims for magnesium.
    Key point
    Laid the foundations for the authorised claims on energy, nervous system, muscle and bones.
    Read the source

The summaries describe each study in plain language. For full details, always consult the original source.

What European regulation recognises

EU-authorised health claim

Magnesium contributes to a reduction of tiredness and fatigue.

EU-authorised health claim

Magnesium and vitamin B6 contribute to normal functioning of the nervous system.

EU-authorised health claim

Magnesium and vitamin B6 contribute to normal psychological function.

Your 2-capsule serving provides 200 mg of magnesium and 6 mg of vitamin B6.

Other timelines